Gamma PNA
Ref. PNG-GAMMA-PNAGamma (γ)-PNA is a backbone-modified PNA incorporating a stereogenic center through substitution at the γ-carbon of the backbone.
About the Product
Gamma (γ)-PNA is a backbone-modified PNA incorporating a stereogenic center through substitution at the γ-carbon of the backbone. This stereogenic center enables γ-PNA oligos to adopt an intrinsic alpha-helical structure, which reduces self-aggregation, improves solubility, and promotes the formation of more stable duplexes with target DNA. These structural features significantly enhance binding affinity, and because modifications can be introduced at any γ-carbon position, diverse applications, including internal multi-labeling, are feasible.
With superior solubility, stable duplex formation, and high binding affinity, γ-PNA is recognized as a highly attractive material for use in diagnostics and drug development.
* The side chain of γ-L-Lys-PNA allows further conjugation of modifications, providing a broad range of structural variations.
Key Features
- Flexibility for internal labeling and multi-labeling
- Enhanced solubility and cell permeability
- Reduced self-aggregation through alpha-helical structure formation
- Superior binding affinity compared to conventional PNA
Technical Characteristics
| Gamma modification | γ-L-Lys-PNA; γ-L-Ala-PNA; γ-L-Glu-PNA; γ-L-GuanidinoLys-PNA; γ-L-Ser-PNA; γ-L-Aminomethylene-PNA; γ-L-Cys-PNA; γ-L-miniPEG-PNA |
|---|---|
| Alpha modification | α-D-Lys-PNA; α-D-Arg-PNA |
| Backbone modification | Gamma(γ)-PNA: Possible | Conventional PNA: Not possible |
| Labeling flexibility on backbone | Gamma(γ)-PNA: O | Conventional PNA: X |
| Water solubility | Gamma(γ)-PNA: Better than conventional PNA | Conventional PNA: – |
| Binding affinity to DNA | Gamma(γ)-PNA: 3–5℃ higher Tm per modified base | Conventional PNA: – |
| ΔTm for single mismatch | Gamma(γ)-PNA: At least 18℃ | Conventional PNA: 15℃ |
| Chemical stability | Gamma(γ)-PNA: Better stability than conventional PNA | Conventional PNA: Stable |
| Thermal stability | Gamma(γ)-PNA: Good | Conventional PNA: Good |
Technical Information
No technical information available for this product.
Compatibility
No compatibility information available for this product.
Packaging
No packaging information available for this product.