Gamma PNA
Ref. PNG-GAMMA-PNAGamma (γ)-PNA is a backbone-modified PNA incorporating a stereogenic center through substitution at the γ-carbon of the backbone.
About the Product
Gamma (γ)-PNA is a backbone-modified PNA incorporating a stereogenic center through substitution at the γ-carbon of the backbone. This stereogenic center enables γ-PNA oligos to adopt an intrinsic alpha-helical structure, which reduces self-aggregation, improves solubility, and promotes the formation of more stable duplexes with target DNA. These structural features significantly enhance binding affinity, and because modifications can be introduced at any γ-carbon position, diverse applications, including internal multi-labeling, are feasible.
With superior solubility, stable duplex formation, and high binding affinity, γ-PNA is recognized as a highly attractive material for use in diagnostics and drug development.
* The side chain of γ-L-Lys-PNA allows further conjugation of modifications, providing a broad range of structural variations.
Technical Characteristics
| Gamma modification | γ-L-Lys-PNAγ-L-Ala-PNAγ-L-Glu-PNAγ-L-GuanidinoLys-PNAγ-L-Ser-PNAγ-L-Aminomethylene-PNAγ-L-Cys-PNAγ-L-miniPEG-PNA |
|---|---|
| Alpha modification |
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| Backbone modification | Gamma(γ)-PNA: Possible | Conventional PNA: Not possible |
| Labeling flexibility on backbone | Gamma(γ)-PNA: O | Conventional PNA: X |
| Water solubility | Gamma(γ)-PNA: Better than conventional PNA | Conventional PNA: – |
| Binding affinity to DNA | Gamma(γ)-PNA: 3–5℃ higher Tm per modified base | Conventional PNA: – |
| ΔTm for single mismatch | Gamma(γ)-PNA: At least 18℃ | Conventional PNA: 15℃ |
| Chemical stability | Gamma(γ)-PNA: Better stability than conventional PNA | Conventional PNA: Stable |
| Thermal stability | Gamma(γ)-PNA: Good | Conventional PNA: Good |
Key Features
- Flexibility for internal labeling and multi-labeling
- Enhanced solubility and cell permeability
- Reduced self-aggregation through alpha-helical structure formation
- Superior binding affinity compared to conventional PNA
Technical Information
No technical information available for this product.
Compatibility
No compatibility information available for this product.
Packaging
No packaging information available for this product.