PNAClamp™ Mutation Detection Kit IDH1
Ref. PNAC-5001Mutations of IDH1 (isocitrate dehydrogenase 1,IDH1) can be found in glioblastoma and myeloproliferative neoplasm. Detection of IDH1mutations can be a positive predictor of a prognosis and a molecular marker for glioblastoma patients.
About the Product
Mutations of IDH1 (isocitrate dehydrogenase 1,IDH1) can be found in glioblastoma and myeloproliferative neoplasm. Detection of IDH1mutations can be a positive predictor of a prognosis and a molecular marker for glioblastoma patients. On the other hand, it is reported that IDH1 mutations correlate with poor prognosis in myeloproliferative neoplasm.
PNAClamp™ IDH1 Mutation Detection Kit is a new member of somatic mutation detection kits utilizing PNA-mediated PCR Clamping technology, and can help patients choose the right medicine and monitor prognosis.
Total 5 IDH1 mutations can be detected.
Technical Characteristics
| Mutations - Codon 132 | 5 |
|---|---|
| Total mutations | 5 |
| Detection limit | 1% LOD with 10 ng wild/mutant type mixed DNA |
| Running time | within 3 hours |
| Procedure | sample preparationExtraction of Total DNAAmplification of target DNA by Real-Time PCRAnalysis of Result |
Key Features
- High sensitivity and specificity even with small amount of DNA (1% LOD with 10 ng wild/mutant type mixed DNA)
- Real-Time PCR based ready-to-use kit
- Short running time (within 3 hours)
Technical Information
No technical information available for this product.
Compatibility
Compatible sample type:
- FFPE tissue
- Fresh tissue
Compatible Real-Time PCR machine:
- CFX96 (Bio-Rad)
- LightCycler 480II (Roche)
- ABI7500 (Thermo Fisher Scientific)
- Rotor-Gene Q (Qiagen)
Packaging
25 tests